Buy Sufentanil Powder

Buy Sufentanil Powder, which is an opponent of opioids. Sufentanil functions as a full opioid antagonist when it comes to activity. An opioid analgesic called sufentanil is utilized as a primary anesthetic drug as well as an adjunct in balanced anesthesia. The intravenous, epidural, and sublingual methods are used to give it.

Also referred to as Dsuvia, the sublingual form is used in approved medically supervised healthcare settings, including hospitals, surgical centers, and emergency rooms, to treat acute pain in adults that is severe enough to need the administration of an opioid analgesic. In the future, the US military may consider using the sublingual version when analgesia is urgently needed.

IUPAC Name
N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide

InChI
InChI=1S/C22H30N2O2S/c1-3-21(25)24(19-8-5-4-6-9-19)22(18-26-2)12-15-23(16-13-22)14-11-20-10-7-17-27-20/h4-10,17H,3,11-16,18H2,1-2H3

InChI Key
GGCSSNBKKAUURC-UHFFFAOYSA-N

Canonical SMILES
CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCC3=CC=CS3)COC

Molecular Formula
C22H30N2O2S

Drug and Medication Information
Drug Indication
The following are the medication’s indications:

1. In patients who are ventilated and intubated, as an additional analgesic to maintain a balanced general anesthetic.

2. In order to provide a favorable myocardial and cerebral oxygen balance or when extended postoperative ventilation is anticipated, as the principal anesthetic agent for the induction and maintenance of anesthesia with 100% oxygen in patients undergoing major surgical procedures, intubated and ventilated patients, such as cardiovascular surgery or neurosurgical procedures, in the sitting position.

3. For the administration of bupivacaine at low doses (typically 12.5 mg per administration) in conjunction with epidural analgesics during labor and vaginal delivery

4. The sublingual form is indicated for the management of acute pain in adults that is severe enough to warrant the use of an opioid analgesic in certified medically supervised healthcare settings, including hospitals, surgical centers, and emergency departments.

Mechanism of Action Buy Sufentanil Powder
A strong synthetic opioid that binds to opioid receptors with extreme selectivity is called sufentanil [F2009]. The human brain, spinal cord, and other tissues contain a large number of these receptors [A39636], [A39637].

Opioids often promote membrane hyperpolarization, reduce neurotransmitter release, and decrease cAMP (affecting brain signaling pathways), all of which help to relieve painful feelings [A39637]. By activating effector proteins through G-proteins, opioid receptors and G-protein receptors together regulate synaptic neuronal transmission in both positive and negative ways. GTP is traded for GDP on the G-protein complex upon opiate receptor binding.

As the effector system is adenylate cyclase and cAMP, located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. The release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is then inhibited [A39637]. Opioids close N-type voltage-operated calcium channels (OP2-receptor agonist), also preventing neurotransmitter release [A39637]. Sufentanil and other opioids open calcium-dependent inwardly rectifying potassium channels, resulting in hyperpolarization and reduced neuronal excitability [A39636, A39637].

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