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Buy Carfentanil POWDER or carfentanyl; is an analogue of fentanyl, a synthetic opioid analgesic. It is fast-acting, short-acting, and has effects that are thousands of times greater than heroin and around 100 times stronger than fentanyl per unit of weight. It outperforms all other opioids in lowering rats’ pain responses.

Paul Janssen and other members of the Janssen Pharmaceutica chemistry team performed the first synthetic synthesis of carbentanil in 1974.

Naloxone can counteract the effects of carfentanil, including overdose.

Although most nations have regulatory restrictions on its use, large animals can be anesthetized using carbentanil in veterinary settings.

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Beginning in 1986, carfentanil was marketed under the name “Wildnil” for use in tranquilizer darts for large mammals, such as elk and elephants, in conjunction with a η2-adrenoreceptor agonist. Because of its strong therapeutic index, it was selected. Wildnil was last produced commercially in 2003, and now it can only be obtained in compounded dose form.

Because of its strong affinity for receptors, radiolabelled [11C]carfentanil is frequently employed as a selective radiotracer in positron emission tomography (PET) imaging studies of the opioid system in both humans and animals.

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According to an Associated Press article from 2016, Chemical Weapon for Sale: China’s unregulated Narcotics, fentanyl, carfentanil and other highly potent derivatives of fentanyl are actively marketed by several Chinese chemical companies. Carfentanil was not a controlled substance in China until March 1, 2017, and until then was manufactured legally and sold openly over the Internet.

In the early 2000s, authorities in Lithuania and Latvia reported finding carfentanil to be an illegal substance. Carfentanil and other potent opioid medications were being shipped in large quantities from Chinese chemical supply companies to customers in North America, according to reports from the US and Canada starting in 2016. The Royal Canadian Mounted Police found a kilogram of carfentanil in a box marked “printer accessories” that had been delivered from China in June 2016.

Containers packaged as toner cartridges for Hewlett-Packard LaserJet printers held 50 million deadly doses of the drug—more than enough to wipe out the entire population of the country—in the cargo, according to the Canada Border Services Agency. Officer-in-charge Allan Lai of the Royal Canadian Mounted Police in Calgary, who assisted in supervising the criminal investigation, stated, “We don’t know why a substance of that potency is coming into our country with respect to carfentanil.”

pharmacological of Because carbentanil is a lipophilic substance, it can pass across the blood-brain barrier much more readily. As a result, it acts quite quickly at first but wears off quickly as well.

For pain relief, a unit of carfentanil is 100 times as potent as the same amount of fentanyl, 5,000 times as potent as a unit of heroin and 10,000 times as potent as a unit of morphine. This is despite only having 14-135 times higher affinity for the ? receptor.

Legal status
China
Carfentanil has been controlled in China since 1 March 2017. The trade war between China and the US has included controversy over the effectiveness of this control.

United States
Carfentanil is classified as Schedule II under the Controlled Substances Act in the United States with a DEA ACSCN of 9743 and a 2016 annual aggregate manufacturing quota of 19 grams (less than 0.7 oz.).

United Kingdom
Carfentanil has been specifically controlled as a Class A drug since 1986

Chemical and physical data
Formula: C24H30N2O3

Molar mass: 394.515 g·mol?1

See also
4-Phenylfentanyl
Lofentanil (3-methylcarfentanyl)
N-Methylcarfentanil
Sufentanil
Thiafentanil
Opioid comparison
R-30490 (4-methoxymethylfentanyl)

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