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BUY PB-22 POWDER; The designer drug (QUPIC, also known as 1-pentyl-1H-indole-3-carboxylic acid 8-quinolinyl ester) was found to be sold in synthetic cannabis products in Japan in 2013 and is marketed as a cannabimimetic by internet merchants. Though its design roots are uncertain, PB-22’s structure seems to draw from knowledge of structure-activity relationships found in the indole class of cannabimimetics.

Because QUPIC has an ester linker at the indole 3-position instead of the amide of APICA and its analogs or the precedented ketone of JWH-018 and its analogs, it represents a chemically distinct synthetic cannabis chemotype. For human CB1 receptors, its EC50 is 5.1 nM, while for human CB2 receptors, it is 37 nM.

At dosages of 0.3 mg/kg, PB-22 causes rats to experience bradycardia and hypothermia, indicating that it has strong cannabinoid-like properties. Compared to JWH-018, AM-2201, UR-144, XLR-11, APICA, or STS-135 rats, PB-22 caused a hypothermic response that was both more severe and lasted longer, with a noticeable drop in body temperature six hours after administration. A human and his dog experienced seizures, and PB-22 was confirmed to be the cause in a clinical toxicological assessment.

Technical Information
Formal Name: 1-(5-fluoropentyl)-8-quinolinyl Ester-1H-indole-3-carboxylic acid
CAS Number: 1400742-41-7
Molecular Formula: C23H21FN2O2
Formula Weight: 376.4
Purity: ?99%
Formulation: A neat solid
InChi CodeInChI=1S/C23H21FN2O2/c24-13-4-1-5-15-26-16-19(18-10-2-3-11-20(18)26)23(27)28-21-12-6-8-17-9-7-14-25-22(17)21/h2-3,6-12,14,16H,1,4-5,13,15H2
DEA Schedule: I
Legal status
As of 9 May 2014, PB-22 is no longer legal in New Zealand.

In January 2014, PB-22 was designated as a Schedule I controlled substance in the United States.

In Ohio, PB-22 is illegal.

Florida has also banned PB-22.

Since December 13, 2014, it is also illegal in Germany because of the addition of the substance to BtMG Anlage II.

As of October 2015, PB-22 is a controlled substance in China

A forensic standard of PB-22 is available, and the compound has been posted on the Forendex website for potential drug abuse.

Shipping & Storage Information
Storage: -20°C
Shipping: Room temperature is in continental US; may vary elsewhere
Stability: ? 3 years
See also

Where to BUY PB-22 POWDER


50g, 100g, 250g, 500g, 1kg


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