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• JWH-210 is a member of the naphthoylindole family of analgesics. It functions as a strong agonist of cannabinoids at both CB1 and CB2 receptors, with Ki values of 0.46 nM at CB1 and 0.69 nM at CB2. Having a higher binding affinity (i.e., lower Ki) at CB1 than both its 4-methyl and 4-n-propyl homologues, JWH-122 (CB1 Ki 0.69 nM) and JWH-182 (CB1 Ki 0.65 nM), respectively, and the 4-methoxy compound JWH-081 (CB1 Ki 1.2 nM), it is one of the most potent 4-substituted naphthoyl derivatives in the naphthoylindole series.[2]It bears John W. Huffman’s name, who made the discovery.